What Is The Difference Between Cortisone and Prednisone?

Summary: Prednisone and cortisone are both glucocorticoid drugs that are used to treat inflammation and immune system disorders. However, prednisone is a much stronger glucocorticoid and is a preferred treatment in conditions like asthma. One of cortisone’s advantages is that it’s available in injectable form and is often used to treat inflammation in joints.

Dear Curtis: This is probably a stupid question but a buddy of mine and I got to arguing the other day about the difference between cortisone and prednisone. I’ve gotten a cortisone shot before and he occasionally takes prednisone for his asthma. He said you couldn’t use cortisone for asthma but, aren’t they both steroids? Don’t they both do the same thing in the body?

Will it help if I say you are both right?

Before I get to the heart of the answer I need to explain some misunderstanding’s that I see a lot with this group of drugs.

First of all, they are all ‘steroids’. Not the type of steroids that certain athletes abuse. But steroids in the sense that they are ‘glucocorticoids’. They’re called steroids because their chemical structure has a ‘steroid’ backbone.

Essentially, both cortisone and prednisone fall into the glucocorticoid class of drugs. Glucocorticoids are naturally produced in your body, especially during times of stress. For example, cortisol is naturally secreted as part of your immune response and helps turn it down so it doesn’t get out of control. Glucocorticoids are also heavily involved in the process of lowering inflammation in our bodies.

Now, for the purpose of you and your friends ‘discussion’ – let’s take his asthma as our example.

Asthma, at it’s heart, is an inflammatory process. In asthmatics their airways become inflamed and, if left untreated, their airways can close up. Now, sometimes the bodies stress response isn’t enough or appropriate and so they need ‘outside’ steroids to help control it. That’s when you start giving the outside glucocorticoids.

You can, and often do, also give asthmatics steroid inhalers so the steroid can get right to the spot of the inflammation and you can avoid some of the body-wide side effects of taking a steroid by mouth.

Using Glucocorticoids In Asthma

I think where you guys are probably getting your wires crossed is about the form of cortisone that is being used.

You see, when you say cortisone you are talking about the shot. One of the advantages of the cortisone shot is just that … it’s a shot. So you can direct it’s effects to exactly where you want them. That’s one of the reasons why you see people who have had, say, a sports injury in their knee where there is inflammation involved. I’ve had cortisone shots in my elbow because of inflammation. The list can go on. And, as you’ll see below, some cortisone shots are followed up with prednisone tablets to be taken by mouth.

But, obviously, you can’t inject cortisone into the lungs to treat asthma. So, in that regard your buddy is right. But cortisone comes in more than one form and is available in an oral tablet as well. Which, technically, could be used to treat asthma.

However, it’s highly likely it won’t be. Why?

If you look at prednisone and compare it to cortisone one major difference will pop up. And that is prednisone is a much stronger glucocorticoid than cortisone. And, as you saw above, a glucocorticoid is something that knocks down the immune response and inflammation.

So, in asthma, which is a disease characterized by inflammation. Prednisone would be the preferred treatment because it’s – on average – five times stronger as a glucocorticoid.


  1. Dale Cannon says:

    I’ve taken cortizone shots in the past (around 10 yrs ago for a shoulder injury) and had no side effects at all…..about 7 yrs ago I was given prednizone orally and caused extreme shortness of breath and worked opposite on me for my asthma. Could I be allergic to prednizone and not be allergic to cortizone?

  2. You may also want to locate a book by Dr. Fred Pescatore, MD. Dr. Pescatore is a licensed physician in New York City who wrote the book, “The Allergy and Asthma Cure.” Dr. Pescatore’s 8-step cure will eliminate the threat of dying from asthma by curing the disease.

    A good friend who had severe asthma and allergies is now free from both as a result of Dr. Pescatore’s fantastic book and research. It is too bad we do not have more doctors like Dr. Pescatore.

  3. i have lupus scleroderma and sjoegrens and been battling serious bladder infection and gyn problems for 11 mnths have damn near died.found some.prednisone to take w antibiodics and now im getting well.it seems i had inflamation in my bladder and urethra..and the scarring from inflamation was leaving open scare tissue to keep being re infected..i decided to try prednisone when i notice mouth and eyes and lungs were burning and stinging like my bladder and urethra was (also vaginal area was affected) realizing i was having flare up and symtoms in many parts of body i desprately asked dr for medrol dose pak..but she wouldnt help me.so i was on my own
    i took 5-10mg prednisone alternately and after mnths of antibiodics and alot of pain amd suffering im starting to kick this and get well after 5 days of sparingly taking prednisone
    im am dxd w MCTD ..thank God i found the steroids ..and now looking for better dr that understands connective tissue diseases or remotely cares..
    jojo chickrock


  1. […] are one of the most effective ways at treating inflammation we have. In addition to that they also can inhibit a number of other factors that can lead to scar […]

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